Remove all invertebrates - these are extremely sensitive to medication. Turn off UV filters, ozone filters, and remove chemical filtration with activated carbon or Purigen. Use 1 measure (included) per every 20 L (5 gallons). Repeat this dose every 48 hours to a maximum of 3 doses. In cases of severe infections, it is possible to carry out two rounds of treatment back-to-back. However, this should only be done if fish show no signs of stress at the end of the first round.